High burden and pervasive positive selection of somatic mutations in normal human skin

How somatic mutations accumulate in normal cells is central to understanding cancer development, but is poorly understood. We performed ultra-deep sequencing of 74 cancer genes in small (0.8-4.7mm(2)) biopsies of normal skin. Across 234 biopsies of sun-exposed eyelid epidermis from four individuals,...

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Pubblicato in:Science
Autori principali: Martincorena, Iñigo, Roshan, Amit, Gerstung, Moritz, Ellis, Peter, Van Loo, Peter, McLaren, Stuart, Wedge, David C., Fullam, Anthony, Alexandrov, Ludmil B., Tubio, Jose M., Stebbings, Lucy, Menzies, Andrew, Widaa, Sara, Stratton, Michael R., Jones, Philip H., Campbell, Peter J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4471149/
https://ncbi.nlm.nih.gov/pubmed/25999502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaa6806
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