High burden and pervasive positive selection of somatic mutations in normal human skin

How somatic mutations accumulate in normal cells is central to understanding cancer development, but is poorly understood. We performed ultra-deep sequencing of 74 cancer genes in small (0.8-4.7mm(2)) biopsies of normal skin. Across 234 biopsies of sun-exposed eyelid epidermis from four individuals,...

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Veröffentlicht in:Science
Hauptverfasser: Martincorena, Iñigo, Roshan, Amit, Gerstung, Moritz, Ellis, Peter, Van Loo, Peter, McLaren, Stuart, Wedge, David C., Fullam, Anthony, Alexandrov, Ludmil B., Tubio, Jose M., Stebbings, Lucy, Menzies, Andrew, Widaa, Sara, Stratton, Michael R., Jones, Philip H., Campbell, Peter J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4471149/
https://ncbi.nlm.nih.gov/pubmed/25999502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaa6806
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