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Universal Patterns of Selection in Cancer and Somatic Tissues

Cancer develops as a result of somatic mutation and clonal selection, but quantitative measures of selection in cancer evolution are lacking. We adapted methods from molecular evolution and applied them to 7,664 tumors across 29 cancer types. Unlike species evolution, positive selection outweighs ne...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Martincorena, Iñigo, Raine, Keiran M., Gerstung, Moritz, Dawson, Kevin J., Haase, Kerstin, Van Loo, Peter, Davies, Helen, Stratton, Michael R., Campbell, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5720395/
https://ncbi.nlm.nih.gov/pubmed/29056346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.09.042
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