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Somatic mutation and clonal expansions in human tissues

Recent sequencing studies on healthy skin and esophagus have found that, as we age, these tissues become colonized by mutant clones of cells carrying driver mutations in traditional cancer genes. This comment summarizes these findings and discusses their possible implications for our understanding o...

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Bibliographic Details
Published in:Genome Med
Main Author: Martincorena, Inigo
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6537184/
https://ncbi.nlm.nih.gov/pubmed/31138277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-019-0648-4
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