Universal Patterns of Selection in Cancer and Somatic Tissues

Cancer develops as a result of somatic mutation and clonal selection, but quantitative measures of selection in cancer evolution are lacking. We adapted methods from molecular evolution and applied them to 7,664 tumors across 29 cancer types. Unlike species evolution, positive selection outweighs ne...

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Udgivet i:Cell
Main Authors: Martincorena, Iñigo, Raine, Keiran M., Gerstung, Moritz, Dawson, Kevin J., Haase, Kerstin, Van Loo, Peter, Davies, Helen, Stratton, Michael R., Campbell, Peter J.
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5720395/
https://ncbi.nlm.nih.gov/pubmed/29056346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.09.042
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