טוען...
High burden and pervasive positive selection of somatic mutations in normal human skin
How somatic mutations accumulate in normal cells is central to understanding cancer development, but is poorly understood. We performed ultra-deep sequencing of 74 cancer genes in small (0.8-4.7mm(2)) biopsies of normal skin. Across 234 biopsies of sun-exposed eyelid epidermis from four individuals,...
שמור ב:
| הוצא לאור ב: | Science |
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| Main Authors: | , , , , , , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2015
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4471149/ https://ncbi.nlm.nih.gov/pubmed/25999502 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaa6806 |
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