Učitavanje...
A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes
Small molecules are useful tools for probing the biological function and therapeutic potential of individual proteins, but achieving selectivity is challenging when the target protein shares structural domains with other proteins. The Bromo and Extra-Terminal (BET) proteins have attracted interest b...
Spremljeno u:
| Izdano u: | Science |
|---|---|
| Glavni autori: | , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2014
|
| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4458378/ https://ncbi.nlm.nih.gov/pubmed/25323695 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1249830 |
| Oznake: |
Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!
|