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Optimization of a “bump-and-hole” approach to allele-selective BET bromodomain inhibition
Allele-specific chemical genetics enables selective inhibition within families of highly-conserved proteins. The four BET (bromodomain & extra-terminal domain) proteins – BRD2, BRD3, BRD4 and BRDT bind acetylated chromatin via their bromodomains and regulate processes such as cell proliferation...
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| Опубликовано в: : | Chem Sci |
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| Главные авторы: | , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Royal Society of Chemistry
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5909127/ https://ncbi.nlm.nih.gov/pubmed/29732121 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7sc02536j |
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