Yüklüyor......
Optimization of a “bump-and-hole” approach to allele-selective BET bromodomain inhibition
Allele-specific chemical genetics enables selective inhibition within families of highly-conserved proteins. The four BET (bromodomain & extra-terminal domain) proteins – BRD2, BRD3, BRD4 and BRDT bind acetylated chromatin via their bromodomains and regulate processes such as cell proliferation...
Kaydedildi:
| Yayımlandı: | Chem Sci |
|---|---|
| Asıl Yazarlar: | , , , , , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Royal Society of Chemistry
2018
|
| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5909127/ https://ncbi.nlm.nih.gov/pubmed/29732121 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7sc02536j |
| Etiketler: |
Etiketle
Etiket eklenmemiş, İlk siz ekleyin!
|