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Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4
[Image: see text] The Bromo- and Extra-Terminal (BET) proteins BRD2, BRD3, and BRD4 play important roles in transcriptional regulation, epigenetics, and cancer and are the targets of pan-BET selective bromodomain inhibitor JQ1. However, the lack of intra-BET selectivity limits the scope of current i...
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| Publicado no: | ACS Chem Biol |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2015
|
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4548256/ https://ncbi.nlm.nih.gov/pubmed/26035625 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00216 |
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