A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes

Small molecules are useful tools for probing the biological function and therapeutic potential of individual proteins, but achieving selectivity is challenging when the target protein shares structural domains with other proteins. The Bromo and Extra-Terminal (BET) proteins have attracted interest b...

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Detaylı Bibliyografya
Yayımlandı:Science
Asıl Yazarlar: Baud, Matthias G. J., Lin-Shiao, Enrique, Cardote, Teresa, Tallant, Cynthia, Pschibul, Annica, Chan, Kwok-Ho, Zengerle, Michael, Garcia, Jordi R., Kwan, Terence T.-L., Ferguson, Fleur M., Ciulli, Alessio
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4458378/
https://ncbi.nlm.nih.gov/pubmed/25323695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1249830
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