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A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes
Small molecules are useful tools for probing the biological function and therapeutic potential of individual proteins, but achieving selectivity is challenging when the target protein shares structural domains with other proteins. The Bromo and Extra-Terminal (BET) proteins have attracted interest b...
में बचाया:
| में प्रकाशित: | Science |
|---|---|
| मुख्य लेखकों: | , , , , , , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2014
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4458378/ https://ncbi.nlm.nih.gov/pubmed/25323695 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1249830 |
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