A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes

Small molecules are useful tools for probing the biological function and therapeutic potential of individual proteins, but achieving selectivity is challenging when the target protein shares structural domains with other proteins. The Bromo and Extra-Terminal (BET) proteins have attracted interest b...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Baud, Matthias G. J., Lin-Shiao, Enrique, Cardote, Teresa, Tallant, Cynthia, Pschibul, Annica, Chan, Kwok-Ho, Zengerle, Michael, Garcia, Jordi R., Kwan, Terence T.-L., Ferguson, Fleur M., Ciulli, Alessio
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4458378/
https://ncbi.nlm.nih.gov/pubmed/25323695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1249830
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