A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes

Small molecules are useful tools for probing the biological function and therapeutic potential of individual proteins, but achieving selectivity is challenging when the target protein shares structural domains with other proteins. The Bromo and Extra-Terminal (BET) proteins have attracted interest b...

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Vydáno v:Science
Hlavní autoři: Baud, Matthias G. J., Lin-Shiao, Enrique, Cardote, Teresa, Tallant, Cynthia, Pschibul, Annica, Chan, Kwok-Ho, Zengerle, Michael, Garcia, Jordi R., Kwan, Terence T.-L., Ferguson, Fleur M., Ciulli, Alessio
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4458378/
https://ncbi.nlm.nih.gov/pubmed/25323695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1249830
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