BRAF(V600E) co-opts a conserved MHC class I internalization pathway to diminish antigen presentation and CD8+ T-cell recognition of melanoma

Oncogene activation in tumor cells induces broad and complex cellular changes that contribute significantly to disease initiation and progression. In melanoma, oncogenic BRAF(V600E) has been shown to drive the transcription of a specific gene signature that can promote multiple mechanisms of immune...

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Publicado en:Cancer Immunol Res
Main Authors: Bradley, Sherille D., Chen, Zeming, Melendez, Brenda, Talukder, Amjad, Khalili, Jahan S., Rodriguez-Cruz, Tania, Liu, Shujuan, Whittington, Mayra, Deng, Wanleng, Li, Fenge, Bernatchez, Chantale, Radvanyi, Laszlo G., Davies, Michael A., Hwu, Patrick, Lizée, Gregory
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4457616/
https://ncbi.nlm.nih.gov/pubmed/25795007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-15-0030
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