BRAF(V600E) co-opts a conserved MHC class I internalization pathway to diminish antigen presentation and CD8+ T-cell recognition of melanoma

Oncogene activation in tumor cells induces broad and complex cellular changes that contribute significantly to disease initiation and progression. In melanoma, oncogenic BRAF(V600E) has been shown to drive the transcription of a specific gene signature that can promote multiple mechanisms of immune...

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Detaylı Bibliyografya
Yayımlandı:Cancer Immunol Res
Asıl Yazarlar: Bradley, Sherille D., Chen, Zeming, Melendez, Brenda, Talukder, Amjad, Khalili, Jahan S., Rodriguez-Cruz, Tania, Liu, Shujuan, Whittington, Mayra, Deng, Wanleng, Li, Fenge, Bernatchez, Chantale, Radvanyi, Laszlo G., Davies, Michael A., Hwu, Patrick, Lizée, Gregory
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4457616/
https://ncbi.nlm.nih.gov/pubmed/25795007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-15-0030
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