BRAF(V600E) co-opts a conserved MHC class I internalization pathway to diminish antigen presentation and CD8+ T-cell recognition of melanoma

Oncogene activation in tumor cells induces broad and complex cellular changes that contribute significantly to disease initiation and progression. In melanoma, oncogenic BRAF(V600E) has been shown to drive the transcription of a specific gene signature that can promote multiple mechanisms of immune...

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Udgivet i:Cancer Immunol Res
Main Authors: Bradley, Sherille D., Chen, Zeming, Melendez, Brenda, Talukder, Amjad, Khalili, Jahan S., Rodriguez-Cruz, Tania, Liu, Shujuan, Whittington, Mayra, Deng, Wanleng, Li, Fenge, Bernatchez, Chantale, Radvanyi, Laszlo G., Davies, Michael A., Hwu, Patrick, Lizée, Gregory
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4457616/
https://ncbi.nlm.nih.gov/pubmed/25795007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-15-0030
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