Vinpocetine Inhibits Streptococcus pneumoniae–Induced Upregulation of Mucin MUC5AC Expression via Induction of MKP-1 Phosphatase in the Pathogenesis of Otitis Media

Mucin overproduction is a hallmark of otitis media (OM). Streptococcus pneumoniae is one of the most common bacterial pathogens causing OM. Mucin MUC5AC plays an important role in mucociliary clearance of bacterial pathogens. However, if uncontrolled, excessive mucus contributes significantly to con...

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Bibliografiska uppgifter
I publikationen:J Immunol
Huvudupphovsmän: Lee, Ji-Yun, Komatsu, Kensei, Lee, Byung-Cheol, Miyata, Masanori, O’Neill Bohn, Ashley, Xu, Haidong, Yan, Chen, Li, Jian-Dong
Materialtyp: Artigo
Språk:Inglês
Publicerad: AAI 2015
Ämnen:
Infectious Disease and Host Response
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4456630/
https://ncbi.nlm.nih.gov/pubmed/25972475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401489
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