Phosphodiesterase 4B Mediates Extracellular Signal-regulated Kinase-dependent Up-regulation of Mucin MUC5AC Protein by Streptococcus pneumoniae by Inhibiting cAMP-protein Kinase A-dependent MKP-1 Phosphatase Pathway

Otitis media (OM) is the most common childhood bacterial infection and the major cause of conductive hearing loss in children. Mucus overproduction is a hallmark of OM. Streptococcus pneumoniae is the most common Gram-positive bacterial pathogen causing OM. Among many mucin genes, MUC5AC has been fo...

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Detalhes bibliográficos
Main Authors: Lee, Jiyun, Komatsu, Kensei, Lee, Byung Cheol, Lim, Jae Hyang, Jono, Hirofumi, Xu, Haidong, Kai, Hirofumi, Zhang, Z. John, Yan, Chen, Li, Jian-Dong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3391144/
https://ncbi.nlm.nih.gov/pubmed/22610099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.337378
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