Vinpocetine Inhibits Streptococcus pneumoniae–Induced Upregulation of Mucin MUC5AC Expression via Induction of MKP-1 Phosphatase in the Pathogenesis of Otitis Media

Mucin overproduction is a hallmark of otitis media (OM). Streptococcus pneumoniae is one of the most common bacterial pathogens causing OM. Mucin MUC5AC plays an important role in mucociliary clearance of bacterial pathogens. However, if uncontrolled, excessive mucus contributes significantly to con...

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書目詳細資料
發表在:J Immunol
Main Authors: Lee, Ji-Yun, Komatsu, Kensei, Lee, Byung-Cheol, Miyata, Masanori, O’Neill Bohn, Ashley, Xu, Haidong, Yan, Chen, Li, Jian-Dong
格式: Artigo
語言:Inglês
出版: AAI 2015
主題:
Infectious Disease and Host Response
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4456630/
https://ncbi.nlm.nih.gov/pubmed/25972475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401489
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