Vinpocetine Inhibits Streptococcus pneumoniae–Induced Upregulation of Mucin MUC5AC Expression via Induction of MKP-1 Phosphatase in the Pathogenesis of Otitis Media

Mucin overproduction is a hallmark of otitis media (OM). Streptococcus pneumoniae is one of the most common bacterial pathogens causing OM. Mucin MUC5AC plays an important role in mucociliary clearance of bacterial pathogens. However, if uncontrolled, excessive mucus contributes significantly to con...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Immunol
Auteurs principaux: Lee, Ji-Yun, Komatsu, Kensei, Lee, Byung-Cheol, Miyata, Masanori, O’Neill Bohn, Ashley, Xu, Haidong, Yan, Chen, Li, Jian-Dong
Format: Artigo
Langue:Inglês
Publié: AAI 2015
Sujets:
Infectious Disease and Host Response
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4456630/
https://ncbi.nlm.nih.gov/pubmed/25972475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401489
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