Vinpocetine Inhibits Streptococcus pneumoniae–Induced Upregulation of Mucin MUC5AC Expression via Induction of MKP-1 Phosphatase in the Pathogenesis of Otitis Media

Mucin overproduction is a hallmark of otitis media (OM). Streptococcus pneumoniae is one of the most common bacterial pathogens causing OM. Mucin MUC5AC plays an important role in mucociliary clearance of bacterial pathogens. However, if uncontrolled, excessive mucus contributes significantly to con...

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Bibliografische gegevens
Gepubliceerd in:J Immunol
Hoofdauteurs: Lee, Ji-Yun, Komatsu, Kensei, Lee, Byung-Cheol, Miyata, Masanori, O’Neill Bohn, Ashley, Xu, Haidong, Yan, Chen, Li, Jian-Dong
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: AAI 2015
Onderwerpen:
Infectious Disease and Host Response
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4456630/
https://ncbi.nlm.nih.gov/pubmed/25972475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401489
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