Vinpocetine Inhibits Streptococcus pneumoniae–Induced Upregulation of Mucin MUC5AC Expression via Induction of MKP-1 Phosphatase in the Pathogenesis of Otitis Media

Mucin overproduction is a hallmark of otitis media (OM). Streptococcus pneumoniae is one of the most common bacterial pathogens causing OM. Mucin MUC5AC plays an important role in mucociliary clearance of bacterial pathogens. However, if uncontrolled, excessive mucus contributes significantly to con...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Lee, Ji-Yun, Komatsu, Kensei, Lee, Byung-Cheol, Miyata, Masanori, O’Neill Bohn, Ashley, Xu, Haidong, Yan, Chen, Li, Jian-Dong
Formato: Artigo
Idioma:Inglês
Publicado em: AAI 2015
Assuntos:
Infectious Disease and Host Response
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4456630/
https://ncbi.nlm.nih.gov/pubmed/25972475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401489
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