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Evidence that TSH Receptor A-Subunit Multimers, Not Monomers, Drive Antibody Affinity Maturation in Graves' Disease

CONTEXT: The TSH receptor (TSHR) A-subunit shed from the cell surface contributes to the induction and/or affinity maturation of pathogenic TSHR autoantibodies in Graves' disease. OBJECTIVE: This study aimed to determine whether the quaternary structure (multimerization) of shed A-subunits infl...

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Bibliografiske detaljer
Udgivet i:J Clin Endocrinol Metab
Main Authors: Rapoport, Basil, Aliesky, Holly A., Chen, Chun-Rong, McLachlan, Sandra M.
Format: Artigo
Sprog:Inglês
Udgivet: Endocrine Society 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4454809/
https://ncbi.nlm.nih.gov/pubmed/25856215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2015-1528
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