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Evidence that Shed Thyrotropin Receptor A Subunits Drive Affinity Maturation of Autoantibodies Causing Graves’ Disease
Context: In Graves’ disease, thyroid-stimulating antibodies (TSAb) activate the TSH receptor (TSHR) causing hyperthyroidism. Serum polyclonal TSAb are difficult to study because of their extremely low serum levels. Objective: Our objective was to determine whether monoclonal TSAb possess characteris...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Endocrine Society
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2681282/ https://ncbi.nlm.nih.gov/pubmed/19066298 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2008-2134 |
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