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Evidence that Shed Thyrotropin Receptor A Subunits Drive Affinity Maturation of Autoantibodies Causing Graves’ Disease
Context: In Graves’ disease, thyroid-stimulating antibodies (TSAb) activate the TSH receptor (TSHR) causing hyperthyroidism. Serum polyclonal TSAb are difficult to study because of their extremely low serum levels. Objective: Our objective was to determine whether monoclonal TSAb possess characteris...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The Endocrine Society
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2681282/ https://ncbi.nlm.nih.gov/pubmed/19066298 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2008-2134 |
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