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Nanoparticles bearing TSH receptor protein and a tolerogenic molecule do not induce immune tolerance but exacerbate thyroid autoimmunity in hTSHR/NOD.H2(h4) mice()
Transgenic NOD.H2(h4) mice that express the human (h)TSHR A-subunit in the thyroid gland spontaneously develop pathogenic TSHR autoantibodies resembling those in patients with Graves’ disease. Nanoparticles coupled to recombinant human TSHR A-subunit protein and a tolerogenic molecule (ITE; ligand f...
Gardado en:
| Publicado en: | J Immunol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6478544/ https://ncbi.nlm.nih.gov/pubmed/30944161 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1900038 |
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