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Nanoparticles bearing TSH receptor protein and a tolerogenic molecule do not induce immune tolerance but exacerbate thyroid autoimmunity in hTSHR/NOD.H2(h4) mice()

Transgenic NOD.H2(h4) mice that express the human (h)TSHR A-subunit in the thyroid gland spontaneously develop pathogenic TSHR autoantibodies resembling those in patients with Graves’ disease. Nanoparticles coupled to recombinant human TSHR A-subunit protein and a tolerogenic molecule (ITE; ligand f...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: McLachlan, Sandra M, Aliesky, Holly A, Rapoport, Basil
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6478544/
https://ncbi.nlm.nih.gov/pubmed/30944161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1900038
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