The Hippo coactivator YAP1 mediates EGFR overexpression and confers chemo-resistance in esophageal cancer

PURPOSE: Esophageal cancer (EC) is an aggressive malignancy and often resistant to therapy. Overexpression of EGFR has been associated with poor prognosis of EC patients. However, clinical trials using EGFR inhibitors have not provided benefit for EC patients. Failure of EGFR inhibition may be due t...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Clin Cancer Res
Päätekijät: Song, Shumei, Honjo, Soichiro, Jin, Jiankang, Chang, Shih-Shin, Scott, Ailing W, Chen, Qiongrong, Kalhor, Neda, Correa, Arlene M., Hofstetter, Wayne L., Albarracin, Constance T., Wu, Tsung-Teh, Johnson, Randy L., Hung, Mien-Chie, Ajani, Jaffer A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2015
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4452384/
https://ncbi.nlm.nih.gov/pubmed/25739674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-2191
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