The Hippo coactivator YAP1 mediates EGFR overexpression and confers chemo-resistance in esophageal cancer

PURPOSE: Esophageal cancer (EC) is an aggressive malignancy and often resistant to therapy. Overexpression of EGFR has been associated with poor prognosis of EC patients. However, clinical trials using EGFR inhibitors have not provided benefit for EC patients. Failure of EGFR inhibition may be due t...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Song, Shumei, Honjo, Soichiro, Jin, Jiankang, Chang, Shih-Shin, Scott, Ailing W, Chen, Qiongrong, Kalhor, Neda, Correa, Arlene M., Hofstetter, Wayne L., Albarracin, Constance T., Wu, Tsung-Teh, Johnson, Randy L., Hung, Mien-Chie, Ajani, Jaffer A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4452384/
https://ncbi.nlm.nih.gov/pubmed/25739674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-2191
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