The Hippo coactivator YAP1 mediates EGFR overexpression and confers chemo-resistance in esophageal cancer

PURPOSE: Esophageal cancer (EC) is an aggressive malignancy and often resistant to therapy. Overexpression of EGFR has been associated with poor prognosis of EC patients. However, clinical trials using EGFR inhibitors have not provided benefit for EC patients. Failure of EGFR inhibition may be due t...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Clin Cancer Res
Main Authors: Song, Shumei, Honjo, Soichiro, Jin, Jiankang, Chang, Shih-Shin, Scott, Ailing W, Chen, Qiongrong, Kalhor, Neda, Correa, Arlene M., Hofstetter, Wayne L., Albarracin, Constance T., Wu, Tsung-Teh, Johnson, Randy L., Hung, Mien-Chie, Ajani, Jaffer A.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2015
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4452384/
https://ncbi.nlm.nih.gov/pubmed/25739674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-2191
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