Differential repair of etheno-DNA adducts by bacterial and human AlkB proteins

AlkB proteins are evolutionary conserved Fe(II)/2-oxoglutarate-dependent dioxygenases, which remove alkyl and highly promutagenic etheno (ε)-DNA adducts, but their substrate specificity has not been fully determined. We developed a novel assay for the repair of ε-adducts by AlkB enzymes using oligod...

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Bibliografiske detaljer
Udgivet i:DNA Repair (Amst)
Main Authors: Zdżalik, Daria, Domańska, Anna, Prorok, Paulina, Kosicki, Konrad, van den Born, Erwin, Falnes, Pål Ø., Rizzo, Carmelo J., Guengerich, F. Peter, Tudek, Barbara
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4451939/
https://ncbi.nlm.nih.gov/pubmed/25797601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2015.02.021
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