Blood brain barrier permeability and tPA-mediated neurotoxicity

Tissue type plasminogen activator (tPA) induces neuronal apoptosis, disrupt the blood-brain-barrier (BBB), and promotes dilation of the cerebral vasculature. The timing, sequence and contributions of these and other deleterious effects of tPA and their contribution to post-ischemic brain damage afte...

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Veröffentlicht in:Neuropharmacology
Hauptverfasser: Nassar, Taher, Yarovoi, Sergey, Rayan, Anwar, Lamensdorf, Itschak, Karakoveski, Michael, Vadim, Polianski, Fanne, Rami Abu, Jamal, Mahmud, Cines, Douglas B., Higazi, Abd Al-Roof
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4423729/
https://ncbi.nlm.nih.gov/pubmed/20060006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2009.12.017
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