tPA-S(481)A Prevents Impairment of Cerebrovascular Autoregulation by Endogenous tPA after Traumatic Brain Injury by Upregulating p38 MAPK and Inhibiting ET-1

Traumatic brain injury (TBI) is associated with loss of cerebrovascular autoregulation, which leads to cerebral hypoperfusion. Mitogen activated protein kinase (MAPK) isoforms ERK, p38, and JNK and endothelin-1 (ET-1) are mediators of impaired cerebral hemodynamics after TBI. Excessive tissue plasmi...

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Bibliografiska uppgifter
Huvudupphovsmän: Armstead, William M., Bohman, Leif-Erik, Riley, John, Yarovoi, Serge, Higazi, Abd Al-Roof, Cines, Douglas B.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Mary Ann Liebert, Inc. 2013
Ämnen:
Original Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3814982/
https://ncbi.nlm.nih.gov/pubmed/23731391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/neu.2013.2962
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