RBC-coupled tPA Prevents Whereas tPA Aggravates JNK MAPK-Mediated Impairment of ATP- and Ca-Sensitive K Channel-Mediated Cerebrovasodilation After Cerebral Photothrombosis

The sole Food and Drug Administration-approved treatment for acute stroke is tissue-type plasminogen activator (tPA), but tPA aggravates impairment of cerebrovasodilation during hypotension in a newborn pig photothrombotic model of stroke. Coupling to carrier red blood cells (RBC) enhances thromboly...

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Bibliographic Details
Main Authors: Armstead, William M., Ganguly, Kumkum, Riley, John, Zaitsev, Sergei, Cines, Douglas B., Higazi, Abd Al-Roof, Muzykantov, Vladimir R.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3619434/
https://ncbi.nlm.nih.gov/pubmed/23577046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12975-011-0105-1
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