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tPA Contributes To Impairment of ATP and Ca Sensitive K Channel Mediated Cerebrovasodilation After Hypoxia/Ischemia Through Upregulation of ERK MAPK

The sole FDA approved treatment for acute stroke is tissue type plasminogen activator (tPA). However, tPA potentiates impairment of pial artery dilation in response to hypotension after hypoxia/ischemia (H/I) in pigs. ATP and Ca sensitive K channels (Katp and Kca) are important regulators of cerebro...

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Bibliografiska uppgifter
Huvudupphovsmän: Armstead, William M., Riley, John, Cines., Douglas B., Higazi, Abd Al-Roof
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3038175/
https://ncbi.nlm.nih.gov/pubmed/21182829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2010.12.052
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