Glucagon Protects Against Impaired NMDA-Mediated Cerebrovasodilation and Cerebral Autoregulation during Hypotension after Brain Injury by Activating cAMP Protein Kinase A and Inhibiting Upregulation of tPA

Outcome of traumatic brain injury (TBI) is impaired by hyperglycemia, hypotension, and glutamate, and improved by insulin. Insulin reduces glutamate concentration, making it uncertain whether its beneficial effect accrues from euglycemia. Glucagon decreases CNS glutamate, lessens neuronal cell injur...

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Bibliographische Detailangaben
Hauptverfasser: Armstead, William M., Kiessling, J. Willis, Cines, Douglas B., Higazi, Abd Al-Roof
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc. 2011
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057207/
https://ncbi.nlm.nih.gov/pubmed/21375400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/neu.2010.1659
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