Glucagon Protects Against Impaired NMDA-Mediated Cerebrovasodilation and Cerebral Autoregulation during Hypotension after Brain Injury by Activating cAMP Protein Kinase A and Inhibiting Upregulation of tPA

Outcome of traumatic brain injury (TBI) is impaired by hyperglycemia, hypotension, and glutamate, and improved by insulin. Insulin reduces glutamate concentration, making it uncertain whether its beneficial effect accrues from euglycemia. Glucagon decreases CNS glutamate, lessens neuronal cell injur...

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Autores principales: Armstead, William M., Kiessling, J. Willis, Cines, Douglas B., Higazi, Abd Al-Roof
Formato: Artigo
Lenguaje:Inglês
Publicado: Mary Ann Liebert, Inc. 2011
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057207/
https://ncbi.nlm.nih.gov/pubmed/21375400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/neu.2010.1659
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