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tPA-A(296-299) Prevents Impairment of Cerebral Autoregulation After Stroke Through LRP Dependent Increase in cAMP and p38

BACKGROUND AND PURPOSE: The sole FDA approved treatment for stroke is tPA, but its brief therapeutic window and complications of treatment constrain its use. One limitation may be its potential to exacerbate impairment of cerebral autoregulation after stroke. Vasodilation is maintained by elevations...

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Detalhes bibliográficos
Publicado no:Stroke
Main Authors: Armstead, William M, Riley, John, Yarovoi, Serge, Higazi, Abd Al-Roof, Cines, Douglas B
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4961526/
https://ncbi.nlm.nih.gov/pubmed/27354223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/STROKEAHA.116.012678
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