tPA-S481A Prevents Neurotoxicity of Endogenous tPA in Traumatic Brain Injury

Traumatic brain injury (TBI) is associated with loss of autoregulation due to impaired responsiveness to cerebrovascular dilator stimuli, which leads to cerebral hypoperfusion and neuronal impairment or death. Upregulation of tissue plasminogen activator (tPA) post-TBI exacerbates loss of cerebral a...

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Detalhes bibliográficos
Main Authors: Armstead, William M., Riley, John, Yarovoi, Serge, Cines, Douglas B., Smith, Douglas H., Higazi, Abd Al-Roof
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2012
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3360893/
https://ncbi.nlm.nih.gov/pubmed/22435890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/neu.2012.2328
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