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Blood brain barrier permeability and tPA-mediated neurotoxicity
Tissue type plasminogen activator (tPA) induces neuronal apoptosis, disrupt the blood-brain-barrier (BBB), and promotes dilation of the cerebral vasculature. The timing, sequence and contributions of these and other deleterious effects of tPA and their contribution to post-ischemic brain damage afte...
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| Publicado no: | Neuropharmacology |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4423729/ https://ncbi.nlm.nih.gov/pubmed/20060006 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2009.12.017 |
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