tPA-S481A Prevents Neurotoxicity of Endogenous tPA in Traumatic Brain Injury

Traumatic brain injury (TBI) is associated with loss of autoregulation due to impaired responsiveness to cerebrovascular dilator stimuli, which leads to cerebral hypoperfusion and neuronal impairment or death. Upregulation of tissue plasminogen activator (tPA) post-TBI exacerbates loss of cerebral a...

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Bibliografiske detaljer
Main Authors: Armstead, William M., Riley, John, Yarovoi, Serge, Cines, Douglas B., Smith, Douglas H., Higazi, Abd Al-Roof
Format: Artigo
Sprog:Inglês
Udgivet: Mary Ann Liebert, Inc. 2012
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3360893/
https://ncbi.nlm.nih.gov/pubmed/22435890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/neu.2012.2328
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