TGFβ responsive tyrosine phosphatase promotes rheumatoid synovial fibroblast invasiveness

OBJECTIVE: In rheumatoid arthritis (RA), fibroblast-like synoviocytes (FLS) that line joint synovial membranes aggressively invade the extracellular matrix, destroying cartilage and bone. As signal transduction in FLS is mediated through multiple pathways involving protein tyrosine phosphorylation,...

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Gepubliceerd in:Ann Rheum Dis
Hoofdauteurs: Stanford, Stephanie M., Aleman Muench, German R., Bartok, Beatrix, Sacchetti, Cristiano, Kiosses, William B., Sharma, Jay, Maestre, Michael F., Bottini, Massimo, Mustelin, Tomas, Boyle, David L., Firestein, Gary S., Bottini, Nunzio
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4422771/
https://ncbi.nlm.nih.gov/pubmed/25378349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2014-205790
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