The Novel Extracellular Cyclophilin A (CyPA) - Inhibitor MM284 Reduces Myocardial Inflammation and Remodeling in a Mouse Model of Troponin I -Induced Myocarditis

Cyclophilins are a group of highly conserved cytosolic enzymes that have a peptidylprolyl cis/trans isomerase activity. Cyclophilin A (CyPA) can be secreted in the extracellular space by inflammatory cells and upon cell death. The presence of CyPA in patients with non-ischemic cardiomyopathy is asso...

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Bibliografski detalji
Izdano u:PLoS One
Glavni autori: Heinzmann, David, Bangert, Anna, Müller, Anna-Maria, von Ungern-Sternberg, Saskia N. I., Emschermann, Frederic, Schönberger, Tanja, Chatterjee, Madhumita, Mack, Andreas F., Klingel, Karin, Kandolf, Reinhard, Malesevic, Miroslav, Borst, Oliver, Gawaz, Meinrad, Langer, Harald F., Katus, Hugo, Fischer, Gunter, May, Andreas E., Kaya, Ziya, Seizer, Peter
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4404136/
https://ncbi.nlm.nih.gov/pubmed/25894208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0124606
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