The Novel Extracellular Cyclophilin A (CyPA) - Inhibitor MM284 Reduces Myocardial Inflammation and Remodeling in a Mouse Model of Troponin I -Induced Myocarditis

Cyclophilins are a group of highly conserved cytosolic enzymes that have a peptidylprolyl cis/trans isomerase activity. Cyclophilin A (CyPA) can be secreted in the extracellular space by inflammatory cells and upon cell death. The presence of CyPA in patients with non-ischemic cardiomyopathy is asso...

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Udgivet i:PLoS One
Main Authors: Heinzmann, David, Bangert, Anna, Müller, Anna-Maria, von Ungern-Sternberg, Saskia N. I., Emschermann, Frederic, Schönberger, Tanja, Chatterjee, Madhumita, Mack, Andreas F., Klingel, Karin, Kandolf, Reinhard, Malesevic, Miroslav, Borst, Oliver, Gawaz, Meinrad, Langer, Harald F., Katus, Hugo, Fischer, Gunter, May, Andreas E., Kaya, Ziya, Seizer, Peter
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4404136/
https://ncbi.nlm.nih.gov/pubmed/25894208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0124606
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