Disrupting the EMMPRIN-Cyclophilin A interaction reduces infarct size and preserves systolic function after myocardial ischemia and reperfusion

INTRODUCTION: Inflammation and proteolysis crucially contribute to myocardial ischemia and reperfusion injury. The Extracellular Matrix Metalloproteinase Inducer (EMMPRIN, CD147) and its ligand Cyclophilin A (CyPA) may be involved in both processes. The aim of the study was to characterize the role...

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Main Authors: Seizer, Peter, Ochmann, Carmen, Schönberger, Tanja, Zach, Sebastian, Rose, Melanie, Borst, Oliver, Klingel, Karin, Kandolf, Reinhard, MacDonald, H. Robson, Nowak, Romana A., Engelhardt, Stefan, Lang, Florian, Gawaz, Meinrad, May, Andreas E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3113549/
https://ncbi.nlm.nih.gov/pubmed/21441138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.111.225771
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