The Novel Extracellular Cyclophilin A (CyPA) - Inhibitor MM284 Reduces Myocardial Inflammation and Remodeling in a Mouse Model of Troponin I -Induced Myocarditis

Cyclophilins are a group of highly conserved cytosolic enzymes that have a peptidylprolyl cis/trans isomerase activity. Cyclophilin A (CyPA) can be secreted in the extracellular space by inflammatory cells and upon cell death. The presence of CyPA in patients with non-ischemic cardiomyopathy is asso...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Heinzmann, David, Bangert, Anna, Müller, Anna-Maria, von Ungern-Sternberg, Saskia N. I., Emschermann, Frederic, Schönberger, Tanja, Chatterjee, Madhumita, Mack, Andreas F., Klingel, Karin, Kandolf, Reinhard, Malesevic, Miroslav, Borst, Oliver, Gawaz, Meinrad, Langer, Harald F., Katus, Hugo, Fischer, Gunter, May, Andreas E., Kaya, Ziya, Seizer, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4404136/
https://ncbi.nlm.nih.gov/pubmed/25894208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0124606
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