Murine Coronavirus Ubiquitin-Like Domain Is Important for Papain-Like Protease Stability and Viral Pathogenesis

Ubiquitin-like domains (Ubls) now are recognized as common elements adjacent to viral and cellular proteases; however, their function is unclear. Structural studies of the papain-like protease (PLP) domains of coronaviruses (CoVs) revealed an adjacent Ubl domain in severe acute respiratory syndrome...

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Détails bibliographiques
Publié dans:J Virol
Auteurs principaux: Mielech, Anna M., Deng, Xufang, Chen, Yafang, Kindler, Eveline, Wheeler, Dorthea L., Mesecar, Andrew D., Thiel, Volker, Perlman, Stanley, Baker, Susan C.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2015
Sujets:
Pathogenesis and Immunity
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403493/
https://ncbi.nlm.nih.gov/pubmed/25694594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00338-15
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