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Assessing Activity and Inhibition of Middle East Respiratory Syndrome Coronavirus Papain-Like and 3C-Like Proteases Using Luciferase-Based Biosensors

Middle East respiratory syndrome coronavirus (MERS-CoV) is associated with an outbreak of more than 90 cases of severe pneumonia with high mortality (greater than 50%). To date, there are no antiviral drugs or specific therapies to treat MERS-CoV. To rapidly identify potential inhibitors of MERS-CoV...

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Detalles Bibliográficos
Main Authors: Kilianski, Andy, Mielech, Anna M., Deng, Xufang, Baker, Susan C.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807373/
https://ncbi.nlm.nih.gov/pubmed/23986593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02105-13
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