A Chimeric Virus-Mouse Model System for Evaluating the Function and Inhibition of Papain-Like Proteases of Emerging Coronaviruses

To combat emerging coronaviruses, developing safe and efficient platforms to evaluate viral protease activities and the efficacy of protease inhibitors is a high priority. Here, we exploit a biosafety level 2 (BSL-2) chimeric Sindbis virus system to evaluate protease activities and the efficacy of i...

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Detalhes bibliográficos
Main Authors: Deng, Xufang, Agnihothram, Sudhakar, Mielech, Anna M., Nichols, Daniel B., Wilson, Michael W., StJohn, Sarah E., Larsen, Scott D., Mesecar, Andrew D., Lenschow, Deborah J., Baric, Ralph S., Baker, Susan C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178736/
https://ncbi.nlm.nih.gov/pubmed/25100850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01749-14
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