Catalytic Function and Substrate Specificity of the Papain-Like Protease Domain of nsp3 from the Middle East Respiratory Syndrome Coronavirus

The papain-like protease (PLpro) domain from the deadly Middle East respiratory syndrome coronavirus (MERS-CoV) was overexpressed and purified. MERS-CoV PLpro constructs with and without the putative ubiquitin-like (UBL) domain at the N terminus were found to possess protease, deubiquitinating, deIS...

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Détails bibliographiques
Publié dans:J Virol
Auteurs principaux: Báez-Santos, Yahira M., Mielech, Anna M., Deng, Xufang, Baker, Susan, Mesecar, Andrew D.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2014
Sujets:
Genome Replication and Regulation of Viral Gene Expression
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4248884/
https://ncbi.nlm.nih.gov/pubmed/25142582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01294-14
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