Analysis of Coronavirus Temperature-Sensitive Mutants Reveals an Interplay between the Macrodomain and Papain-Like Protease Impacting Replication and Pathogenesis

Analysis of temperature-sensitive (ts) mutant viruses is a classic method allowing researchers to identify genetic loci involved in viral replication and pathogenesis. Here, we report genetic analysis of a ts strain of mouse hepatitis virus (MHV), tsNC11, focusing on the role of mutations in the mac...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Deng, Xufang, Mettelman, Robert C., O’Brien, Amornrat, Thompson, John A., O’Brien, Timothy E., Baker, Susan C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6613754/
https://ncbi.nlm.nih.gov/pubmed/30918076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02140-18
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