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Stabilization of G protein-coupled receptors by point mutations

G protein-coupled receptors (GPCRs) are flexible integral membrane proteins involved in transmembrane signaling. Their involvement in many physiological processes makes them interesting targets for drug development. Determination of the structure of these receptors will help to design more specific...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Front Pharmacol
Hauptverfasser: Heydenreich, Franziska M., Vuckovic, Ziva, Matkovic, Milos, Veprintsev, Dmitry B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403299/
https://ncbi.nlm.nih.gov/pubmed/25941489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2015.00082
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