Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation

Cellular functions of arrestins are determined in part by the pattern of phosphorylation on the G protein-coupled receptors (GPCRs) to which arrestins bind. Despite high-resolution structural data of arrestins bound to phosphorylated receptor C-termini, the functional role of each phosphorylation si...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Mayer, Daniel, Damberger, Fred F., Samarasimhareddy, Mamidi, Feldmueller, Miki, Vuckovic, Ziva, Flock, Tilman, Bauer, Brian, Mutt, Eshita, Zosel, Franziska, Allain, Frédéric H. T., Standfuss, Jörg, Schertler, Gebhard F. X., Deupi, Xavier, Sommer, Martha E., Hurevich, Mattan, Friedler, Assaf, Veprintsev, Dmitry B.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6424980/
https://ncbi.nlm.nih.gov/pubmed/30890705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09204-y
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