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A Rapid and Efficient Building Block Approach for Click Cyclization of Peptoids

Cyclic peptide-peptoid hybrids possess improved stability and selectivity over linear peptides and are thus better drug candidates. However, their synthesis is far from trivial and is usually difficult to automate. Here we describe a new rapid and efficient approach for the synthesis of click-based...

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Detalhes bibliográficos
Publicado no:Front Chem
Main Authors: Samarasimhareddy, Mamidi, Shamir, Mai, Shalev, Deborah E., Hurevich, Mattan, Friedler, Assaf
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7248394/
https://ncbi.nlm.nih.gov/pubmed/32509731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2020.00405
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