Cyclizing Painkillers: Development of Backbone-Cyclic TAPS Analogs

Painkillers are commonly used medications. Native peptide painkillers suffer from various pharmacological disadvantages, while small molecule painkillers like morphine are highly addictive. We present a general approach aimed to use backbone-cyclization to develop a peptidomimetic painkiller. Backbo...

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Bibliografiske detaljer
Udgivet i:Front Chem
Main Authors: Talhami, Alaa, Swed, Avi, Hess, Shmuel, Ovadia, Oded, Greenberg, Sarit, Schumacher-Klinger, Adi, Rosenthal, David, Shalev, Deborah E., Hurevich, Mattan, Lazarovici, Philip, Hoffman, Amnon, Gilon, Chaim
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7689096/
https://ncbi.nlm.nih.gov/pubmed/33282822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2020.532577
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